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KMID : 0377820000200030264
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Diagnosis and Treatment
2000 Volume.20 No. 3 p.264 ~ p.267
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A Case of Peripheral T-cell Lymphoma associated with HIV Infection
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Abstract
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Diseases of oral and pharyngeal mucosa arising in patients with AIDS are candidiasis, hairy leukoplakia, aphthous stomatitis, herpes stomatitis and others. Kaposi´s sarcoma and non-Hodgkin´s lymphoma are seen frequently in AIDS patients but peripheral T-cell lymphoma is much less common than B-cell lymphoma. When present, however, HIV-associated T-cell ,lymphomas may also have evidence of infection with the Epstein-Barr virus (EBV), similar to HIV-associated B-cell lymphomas. In this case we described one case of EBV negative, peripheral T-cell lymphoma in HIV positive patient. Patient was a 33-year-old man diagnosed with HIV positive in admission lab after the development of oropharyngeal deep ulcer resistant to medical treatment. He developed 2x3cm sized painful deep ulcer on uvula and anterior tonsillar pillar 40 days ago. Oral mucosa biopsy showed that the large lymphocytes were surrounding and infiltrating the blood vessel. Immunostaining showed that the lymphocytes expressed T-cell-associated antigens, including CD3, UCHL1 and negative for B-lineage-associated antigens. Polymerase chain reaction was negative for the EBV. The purpose of this article is to present a case of peripheral T-cell lymphoma in HIV positive patient and to give a special emphasis on the significance of mucosal biopsy in patient with oropharyngeal ulcerative disease resistant to medical treatment.
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KEYWORD
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